AB0311 INCREASED LEVELS OF SERUM WISTERIA FLORIBUNDA AGGLUTININPOSITIVE MAC-2 BINDING PROTEIN IN RHEUMATIC DISEASES INCLUDING SLE

Background: Mac-2 binding protein is a cell-adhesive glycoprotein of the extracellular matrix secreted as ligand galectin-3 (Mac-2). Recently, Wisteria floribunda agglutinin positive-M2BP (M2BP) assay developed using lectin-antibody sandwich immunoassay has shown promise new fibrotic marker in liver fibrosis and interstitial lung disease (ILD) to detect unique fibrosis-related glycoalteration. Objectives: The aim this study evaluate utility serum glycosylation isomer (M2BPGi) levels patients with rheumatic diseases (RD). Methods: We retrospectively measured M2BPGi 68 RD 16 healthy controls (HC). There were no cirrhosis active hepatitis. Serum HISCL M2BP Assay Kit. examined relationship between clinical parameters RD. Results: In RD, median age was 62.0 years 79.4% them female. significantly higher than HC (median 0.98 cutoff index [COI], 0.32 COI, respectively; P < 0.00001). Patients SLE tended have other diseases. significant correlation not found inflammation markers such CRP or ferritin. However, correlated B cell activation immunoglobulin free light chain IgG (r = 0.588, 0.504) T sIL-2R 0.408). Conclusion: Most considered be type I interferonopathy rheumatoid arthritis, Sjogren’s syndrome, inflammatory myositis, scleroderma SLE. reported activity [SS Ahn et al. Lupus. 2018; 27: 771], also Gakectin-9, novel biomarker for IFN signiture [Lucas L van den Hoogen Ann Rheum Dis. 77: 1810]. So, it suggested that may indirectly indicates how much activated Disclosure Interests: None declared